The Power of Lubrication: Noltrex®Vet’s Role in Long-Term Joint Care

Managing osteoarthritis (OA) in horses requires a comprehensive approach that supports joint function while addressing pain and inflammation. Noltrex®Vet is a synthetic polyacrylamide hydrogel designed to provide long-lasting lubrication and cartilage protection by reducing friction within the joint. Noltrex®Vet physically supports joint function and plays a vital role in a multi-modal treatment plan by improving joint mechanics and complementing other therapies that are aimed at managing inflammation, pain, and tissue healing.

Noltrex®Vet’s unique characteristics provide multiple benefits, including:

  • Enhanced Lubrication – Reduces friction between joint surfaces, promoting smoother movement and improved mobility.
  • Prolonged Action – Noltrex®Vet persists for several weeks following injection.
  • Targeted Tissue Support – Localizes at the area of need, offering superior lubrication and cartilage protection from friction.

Protecting cartilage integrity is essential in managing equine OA. The wear and tear from high-impact activities can cause pain and accelerate joint deterioration. By forming a protective lubricating layer on the cartilage, Noltrex®Vet supports an optimal environment for long-term joint health, offering an innovative approach to joint care.

Description 1

The Noltrex®Vet, stained fluorescent green, is seen here forming a layer on the cartilage in areas of damage. Images A and B are healthy cartilage. Cartilage damage due to inflammation is represented by image C, and trauma damage by image D. (Vishwanath, McClure & Bonassar, 2023)

Description 2

Fluorescently stained Noltrex®Vet, demonstrating presence on the cartilage surface in the fetlocks of horses. Cartilage explants had lower friction, confirming the presence and function of the gel at the cartilage surface. (Vishwanath, McClure & Bonassar, 2024)

References:

Vishwanath, K., McClure, S. R., & Bonassar, L. J. (2023). Polyacrylamide hydrogel lubricates cartilage after biochemical degradation and mechanical injury. Journal of Orthopedic Research, 41(1), 63-71.

Vishwanath, K., McClure, S. R., & Bonassar, L. J. (2024). Heterogeneous distribution of viscosupplements in vivo is correlated to ex vivo frictional properties of equine cartilage. Journal of Biomedical Materials Research – Part A.

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